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LTC8K6
Joined: 20 Oct 2000
Posts: 267
Location: Tar Heel State |
Maxygen
 Sat Nov 04, 2000 7:56 pm
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Part of Maxygen's press release:
"Aerosol delivery of prophylactic and therapeutic agents is potentially the simplest and most cost-effective way to protect or treat humans and animals from disease epidemics. In addition to this recent DARPA grant, Maxygen is the recipient of two additional DARPA grants in the vaccine area. In February 1998, Maxygen received a $5.6 million grant to evolve novel DNA vectors for efficient delivery and expression of pathogen antigens, and in April 1999, the Company received a grant of $7.7 million to generate novel vaccine antigens for a wide range of pathogens."
Why couldn't this be for inhalers of the type that asthmatics and veterinarians currently use? I for one, would rather not get stuck with needles anymore.
I am pretty sure this was discussed by myself and others a while ago on Cliff's board. I believe my theory and my person were laughed off at the time.
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Thermit
Joined: 08 Jul 2000
Posts: 3136
Location: Texas |
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Sat Nov 04, 2000 11:59 pm
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LTC, you could be right.
Look what else DARPA is paying Maxygen for: A way to decontaminate people, equipment and the environment after a biological warfare attack. We may not know about the aerosol vaccinations, but I don't think they are going to use inhalers for decontam of the environment. They are gonna have to spray that stuff everywhere...
http://www.darpa.mil/dso/thrust/bwd/upc/0034.html
quote:
Pathogenic spore-forming bacteria like Bacillus anthracis, Clostridium botulinum, C. difficile, C. perfringens and C. tetani form spores which survive in harsh environmental conditions for extended periods of time........The possible use of spores in BW or terrorist activities argues for an enzyme-based, broad spectrum decontamination formulation for personnel, equipment and environment.
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Swedishoo
Joined: 09 Aug 2000
Posts: 429
Location: NC |
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Sun Nov 05, 2000 1:37 am
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This is pretty creepy stuff..It continues to say...
"The spore nucleoid structure is surrounded by protective layers composed of peptidoglycan and proteins with unusual amino acids content. This structure provides unique resistance properties acting as a permeability barrier to prevent access to the underlying spore protoplast. Spores are able to survive exposure to chlorinated solvents, detergents, mechanical disruption, extreme temperatures, UV and ionizing radiation. These organisms can be bioengineered to maximize pathogenicity and the spores easily weaponized and stored."
They say that DNA shuffling is a revolutionary method for directed evolution in destroying these spores...but wouldn't the DNA shuffling only allow certain races to be protected if desired??
Christy |
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theseeker
Joined: 25 Jul 2000
Posts: 3403
Location: Damnit...I'm a doctor jim |
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Sun Nov 05, 2000 9:19 am
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>but wouldn't the DNA shuffling only allow certain races to be protected if desired??<
That's the chromosome level, I think...or "chrosome" as archie bunker refers to it.....
You are infering that selected off shoots of man would benift or be affected adversely...
correct ?
Who is they say ?
------------------
T/S
[Edited 1 times, lastly by theseeker on 11-05-2000] |
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Swedishoo
Joined: 09 Aug 2000
Posts: 429
Location: NC |
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Sun Nov 05, 2000 6:17 pm
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Who is they say ?
Seeker, at that url Thermit gave, that is what "they" were discussing...the methods of killing Biological Warfare spores. My thouhgts were, if they do this through a DNA shuffle, could it be a selective shuffle depending on certain DNA codes and patterns?
Christy |
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Thermit
Joined: 08 Jul 2000
Posts: 3136
Location: Texas |
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Sun Nov 05, 2000 8:49 pm
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quote:
Our DNAShuffling technologies work as follows: a single gene or multiple genes are cleaved into fragments and recombined creating a population of novel gene sequences. The novel genes created by DNAShuffling are then selected for one or more desired characteristics. This selection process yields a population of genes which becomes the starting point for the next cycle of recombination. As with classical breeding, this process is repeated until genes expressing the desired properties are identified.
For what ever that's worth... |
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