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Inhalation:
Upon prolonged and/or repeated exposure, can cause moderate
respiratory irritation, dizziness, weakness, fatigue, nausea and
headache.Harmful! Can cause systemic damage upon prolonged and/or
repeated exposure (see "Target Organs)
Skin Absorption:
Upon prolonged or repeated exposure, harmful if absorbed through the
skin. May cause severe irritation and systemic damage
31254, 31254-5XX, & 31354 / JP-8 Standard
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toxdoc
Registered User
Posts: 87
(1/28/02 9:29:15 pm)
Reply Hey Jay
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Hmmm, while I think his work with rodents is good, the problem is it is in rodents. In some cases rodents are very good models for humans, in other cases they aren't. In regards to the immunotoxicology studies mice are just not very good models for humans. They are really sensitive to immunological insult, and most any stress causes them to mount really overblown inflammatory responses. It's a really complex process but, you see it pretty much if you look for it. The fact that substance P and anti-inflammatories can prevent a lot of the adverse responses is pretty indicative that this is not so much a specific toxicity but, just some really stressed mice. I've seen similar results with many different agents, including getting near complete loss of the thymus with toxic but, non-lethal doses of acetaminophen. Lung presents a similar problem, again the rat is a really sensitive species that is just not a great human model. Are jet fuels causing some of the clusters in places like Falon? Not likely. It's really difficult to ever pinpoint a cause and really there has never been any real exposures or releases to justify worry. In truth, there's probably more exposure to benzene and such when a car with a half tank of gas is in an attached garage. And really, just because you can measure something it's not a big deal unless you increase threshold doses. Clusters are all to often just random clumps, no specific reason for them they are just statistical flukes. Take a 100 pennies, put them in a box and shake them up. Then define a sampling technique (say a 4 *4 square) and only look for heads up coins in the 4*4 square, you'll see lots of clusters. John Brignel of the Numberwatch web site has some far better examples of clustering than I ( http://www.numberwatch.co.uk/ ) .

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