posted 12-04-2000 05:58 PM
Thermit....Check out this web site.
http://www.nbc-med.org/SiteContent/MedRef/OnlineRef/FieldManuals/medman/Cover.htm Click all the known biological warfare agents on the left and check out the vaccines available. Then check out how they need to be dispensed, and at what amounts... to be effective.
Can you imagine the COMBINED side affects , if you mixed these vaccines together to produce millions and millions of gallons for use in aerial spray applications. One whiff of that baby and you would hit the floor before you had a chance to exhale.
It’s time to put this theory to bed Thermit. What else you got?
Vaccine: (Smallpox) Smallpox vaccine (vaccinia virus) is most often administered by intradermal inoculation with a bifurcated needle, a process that became known as scarification because of the permanent scar that resulted. Vaccination after exposure to weaponized smallpox or a case of smallpox is effective in preventing disease if given within 7 days after exposure. A vesicle typically appears at the vaccination site 5-7 days post-inoculation, with surrounding erythema and induration. The lesion forms a scab and gradually heals over the next 1-2 weeks.
Vaccine: (Anthrax) A licensed vaccine is derived from sterile culture fluid supernatant taken from an attenuated strain. The vaccination series consists of six 0.5 ml doses SC at 0, 2, and 4 weeks, then 6, 12 and 18 months, followed by yearly boosters. Limited human data suggest that the vaccine protects against cutaneous anthrax. There is insufficient data to know its efficacy against inhalational anthrax in humans, although studies in rhesus monkeys indicate that good protection can be afforded after only two doses (15 days apart) for up to 2 years. However, it should be emphasized that the vaccine series should be completed according to the routine 6 dose primary series. As with all vaccines, the degree of protection depends upon the magnitude of the challenge dose; vaccine-induced protection could presumably be overwhelmed by extremely high spore challenge.
Vaccine: (Brucellosis) Live animal vaccines are used widely. Consumption of unpasteurized milk and cheese should be avoided. No approved human brucella vaccine is available. An experimental human brucellosis vaccine has been tested on 271 subjects with a 25% rate of unpleasant acute side effects, but no long term adverse side effects.
Vaccine: (Cholera) A licensed, killed vaccine is available for use in those considered to be at risk of exposure, however, it provides only about 50 percent protection that lasts for no more than 6 months. The vaccination schedule is an initial dose followed by a second dose 4 weeks later, with booster doses every 6 months. An inactivated oral vaccine (WC/rBS), which is licensed in Europe, is safe and provides rapid short-term protection. Licensure in the US is anticipated. WC/rBS requires 2 doses and has approximately 85% efficacy lasting 2-3 years for both El Tor and classical biotypes. Live attenuated oral vaccines show much promise, and one, CVD 103-HgR (classical biotype), will probably be available by 1999. There are no O139 serogroup vaccines close to licensure, and none of the above mentioned vaccines provide cross-protection against O139. Primary infection with V. cholerae O1 serogroup also provides no immunity against O139.
Vaccine: (Glanders) There is no vaccine available for human use.
Vaccine: (Plague) A licensed, killed whole cell vaccine is available for use in those considered to be at risk of exposure. The primary series consists of three doses. The initial dose of 1.0 ml IM followed by 0.2 ml IM at 1 and 6 months. Three booster doses of 0.2 ml IM are given at 6 month intervals following the third dose of the primary series and then every 1-2 years thereafter. The current vaccine offers protection against bubonic plague, but is probably not effective against aerosolized Y. pestis. Presently, 8-10 percent of inoculations result in local reactions which include erythema, induration, tenderness and edema at the site of injection. These typically resolve within 48 hours. Approximately 7-10 percent of inoculations will result in systemic symptoms including malaise, lymphadenopathy, fever and very rarely anaphylaxis, tachycardia, urticaria, or hypotension.
Vaccine: (Tularemia) A live, attenuated tularemia vaccine is available as an investigational new drug (IND). It is given by scarification. This vaccine has been administered to more than 5,000 persons without significant adverse reactions. It is of proven effectiveness in preventing laboratory acquired tularemia as well as in experimentally exposed human volunteers. As with all vaccines, the degree of protection depends upon the magnitude of the challenge dose; vaccine-induced protection could be overwhelmed by extremely high doses.
Vaccine: (Q fever) A formalin-inactivated whole cell vaccine is available for immunization of at-risk personnel on an investigational basis, although a Q fever vaccine is licensed in Australia. Vaccination with a single dose of this killed suspension of C. burnetii provides complete protection against naturally occurring Q fever, and greater than 95 percent protection against aerosol exposure. Protection lasts for at least 5 years. The vaccine is generally safe in nonsensitized individuals. However, administration of this vaccine in immune individuals may cause severe local reactions including large areas of induration, sterile abscess formation, and even necrosis at the inoculation site. Newer vaccines are under development for use in sensitized persons.
Vaccine: (Venezuelan equine encephalitis) An investigational vaccine, designated TC-83, is a live, attenuated cell-culture-propagated vaccine which has been used in several thousand persons to prevent laboratory infections. The vaccine is given as a single 0.5 ml subcutaneous dose. Febrile reactions occur in up to 18 percent of persons vaccinated, and may be moderate to severe in 5 percent, with fever, myalgias, headache, and prostration. Approximately 18 percent of vaccinees fail to develop detectable neutralizing antibodies, but it is unknown whether they are susceptible to clinical infection if challenged. Contraindications for use include an intercurrent viral infection or pregnancy. TC-83 is a licensed vaccine for Equidae.
A second investigational product that has been tested in humans is the C-84 vaccine, prepared by formalin-inactivation of the TC-83 strain. The vaccine is not used for primary immunization, but is currently used to boost nonresponders to TC-83 (0.5 ml subcutaneously at 2-4 week intervals for up to 3 inoculations or until an antibody response is measured), and probably affords complete protection against aerosol infection from homologous strains in these individuals. As with all vaccines, the degree of protection depends upon the magnitude of the challenge dose; vaccine-induced protection could be overwhelmed by extremely high doses.
Vaccine: (Ebolia) The only established and licensed virus-specific vaccine available for any of the hemorrhagic fever viruses is Yellow Fever vaccine, which is mandatory for travelers to endemic areas of Africa and South America. Argentine hemorrhagic fever (AHF) vaccine is a live, attenuated, investigational vaccine developed at USAMRIID, which has proved efficacious both in an animal model and in a field trial in South America, and seems to protect against Bolivian hemorrhagic fever (BHF) as well. Both inactivated and live-attenuated Rift Valley fever vaccines are currently under investigation. There is no currently available vaccine for either the filoviruses or for dengue.
Vaccine: (Staphylococcal enterotoxin B) Although there is currently no human vaccine for immunization against SEB intoxication, several vaccine candidates are in development. Preliminary animal studies have been encouraging and a vaccine candidate is nearing transition to advanced development and safety and immunogenicity testing in man. Experimentally, passive immunotherapy can reduce mortality, but only when given within 4-8 hours after inhaling SEB.
Vaccine: (Botulinum toxins ) A pentavalent toxoid of Clostridium botulinum toxin types A, B, C, D, and E is available under an IND status. This product has been administered to several thousand volunteers and occupationally at-risk workers, and induces serum antitoxin levels that correspond to protective levels in experimental animal systems. The currently recommended primary series of 0, 2, and 12 weeks, then a 1 year booster induces protective antibody levels in greater than 90 percent of vaccinees after one year. Adequate antibody levels are transiently induced after three injections, but decline prior to the one year booster.
Contraindications to the vaccine include sensitivities to alum, formaldehyde, and thimerosal, or hypersensitivity to a previous dose. Reactogenicity is mild, with two to four percent of vaccinees reporting erythema, edema, or induration at the local site of injection which peaks at 24 to 48 hours, then dissipates. The frequency of such local reactions increases with each subsequent inoculation; after the second and third doses, seven to ten percent will have local reactions, with higher incidence (up to twenty percent or so) after boosters. Severe local reactions are rare, consisting of more extensive edema or induration. Systemic reactions are reported in up to three percent, consisting of fever, malaise, headache, and myalgia. Incapacitating reactions (local or systemic) are uncommon. The vaccine should be stored at refrigerator temperatures (not frozen).
Vaccines: (Ricin) The protective mask is effective in preventing aerosol exposure. Although a vaccine is not currently available, candidate vaccines are under development which are immunogenic and confer protection against lethal aerosol exposures in animals. Prophylaxis with such a vaccine is the most promising defense against a biological warfare attack with ricin.
Vaccines: (Trichothecene mycotoxins ) Physical protection of the skin and airway are the only proven effective methods of protection during an attack. Immunological (vaccines) and chemoprotective pretreatments are being studied in animal models, but are not available for field use by the warfighter.
[Edited 5 times, lastly by elvis lives on 12-04-2000]